There are some suggestion that obesity weight loss may hard to achieve for certain obese adult as a result of low levels of growth hormone that can lead to an anabolic effect by increasing insulin-like growth factor (IGF)-I.
In a 12-week randomized, double-blind and placebo-controlled trial by Division of Endocrinology, Department of Internal Medicine, YongDong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea (1), of 22 women and 2 men age from 22-46 years old were fed a diet of 25 kcal/kg ideal body weight (IBW) with 1.2 g protein/kg IBW daily and were treated with recombinant human GH (n = 12, 0.18 U/kg IBW/week) or placebo (n = 12, vehicle injection). researchers reported that GH treatment caused a 1.6-fold increase in the fraction of body weight lost as fat and a greater loss of visceral fat area than placebo treatment (35.3 vs. 28.5%, p < 0.05).
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(1) `Low-dose growth hormone treatment with diet restriction accelerates body fat loss, exerts anabolic effect and improves growth hormone secretory dysfunction in obese adults.` by Kim KR, Nam SY, Song YD, Lim SK, Lee HC, Huh KB., posted in PubMed