Long-term effects of an inpatient weight-loss program

In the investigation of effectiveness of dietary treatment in children with simple obesity on the basis of thorough analysis of their state of nutrition, method of nutrition and eating habits and the impact of other environmental factors, conducted by Zakład Zywienia, Instytut Matki i Dziecka, ul. Kasprzaka, researchers found that
1. Simple obesity in children aged 3-15 yrs is connected with familial and environmental factors, including incorrect eating habits.
2. Dietary treatment consisting in the lowering of energetic value of the diet through the reduction of fat consumption and quantity and quality changes with respect to carbohydrates consumption decreased the children's obesity, and was more effective in the older age group (7-15 yrs). Dietary treatment normalizes the lipid profile in children.
3. Significant body mass loss has been observed in children in whose diet the amount of proteins and their share in the total energy value only slightly differs from the level before the dietary treatment. The amount of proteins in the children's diet was within the range of physiological recommendations.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "[Simple obesity in children. A study on the role of nutritional factors].[Article in Polish]" by

Weker H.

short-term lifestyle intervention in the insulin sensitive phenotype of obesity.

In the study of 3-month lifestyle intervention on insulin sensitivity and its related cardiometabolic factors in obese patients, conducted by Department of Medical Sciences and Rehabilitation(1)
found that Lifestyle intervention induces changes in insulin sensitivity and metabolic factors that depend on the pre-intervention degree of insulin sensitivity. Weight loss leads to metabolic benefits in insulin-resistant, obese patients, whereas it may paradoxically worsen the metabolic conditions in the insulin-sensitive phenotype of obesity(1)

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight


(1) "Insulin sensitivity deteriorates after short-term lifestyle intervention in the insulin sensitive phenotype of obesity" by Gilardini L, Vallone L, Cottafava R, Redaelli G, Croci M, Conti A, Pasqualinotto L, Invitti C.

Endurance training per se increases metabolic health

In the study of In a randomized, controlled trial we compared the effects of endurance training with or without weight loss to the effect of weight loss induced by an energy-reduced diet in 48 sedentary, moderately overweight men who completed a 12-week intervention program of training (T), energy-reduced diet (D), training and increased diet (T-iD), or control (C). An energy deficit of 600 kcal/day was induced by endurance training or diet in T and D and a similar training regimen plus an increased dietary intake of 600 kcal/day defined the T-iD group, researchers found that endurance training per se increases various metabolic health parameters and that endurance training should preferably always be included in any intervention regimen for improving metabolic health in moderately overweight men.(1)

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight


(1) "Endurance training per se increases metabolic health in young, moderately overweight men" by Nordby P, Auerbach PL, Rosenkilde M, Kristiansen L, Thomasen JR, Rygaard L, Groth R, Brandt N, Helge JW, Richter EA, Ploug T, Stallknecht B.

Weight Loss and Very Low Calorie Diet

In the investigation of investigate the effect of weight loss due to a very low calorie diet (VLCD) on insulin sensitivity and IL-6 serum levels in nondiabetic obese human individuals. 10 patients with obesity were examined during 12 weeks of a VLCD (800 kcal/d). Body composition was measured by impedance analysis, found that despite improvement of insulin sensitivity, IL-6 serum levels did not change throughout the study period, suggesting that in nondiabetic obese human subjects IL-6 might have only a minor role in the impairment of insulin sensitivity.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Weight Loss Due to a Very Low Calorie Diet Differentially Affects Insulin Sensitivity and Interleukin-6 Serum Levels in Nondiabetic Obese Human Subjects" by Oberhauser F, Schulte DM, Faust M, Güdelhöfer H, Hahn M, Müller N, Neumann K, Krone W, Laudes M.

Weight loss improves renal hemodynamics

Renal hemodynamics is a study of as blood movement of blood flow or the circulation in the kidney.
According to the study of thirty-five obese patients undertook a 12-week calorie-restricted diet. The patients underwent a metabolic (oral glucose tolerance test, plasma lipids, and uric acid) and renal hemodynamic evaluations (creatinine clearance and urinary albumin excretion) before (phase 1), and after the 12-week diet (phase 2), researchers found that Body weight reduction has a positive impact on renal hemodynamics, decreasing urinary albumin excretion as well as glomerular hyperfiltration in obese patients with metabolic syndrome(1)

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Weight loss improves renal hemodynamics in patients with metabolic syndrome"

Ezequiel DG, Costa MB, Chaoubah A, Paula RB.

Supplementation with conjugated linoleic acid for 24 months and Body fat mass in healthy, Overweight humans.

Conjugated linoleic acids (CLA) are a family of over 28 isomers of linoleic acid found abundantly in the meat and dairy products.
After 12 mo in a randomized, double-blind, placebo-controlled trial of conjugated linoleic acid (CLA) supplementation (2 groups received CLA as part of a triglyceride or as the free fatty acid, and 1 group received olive oil as placebo), 134 of the 157 participants who concluded the study were included in an open study for another 12 mo, with all subjects were supplemented with 3.4g CLA/d in the triglyceride form conducted by Scandinavian Clinical Research AS (1), found that LBM and BMM were not affected in any of the groups. Changes in body composition were not related to diet and/or training. In conclusion, this study shows that CLA supplementation for 24 mo in healthy, overweight adults was well tolerated. It confirms also that CLA decreases BFM in overweight humans, and may help maintain initial reductions in BFM and weight in the long term.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans" Gaullier JM, Halse J, Høye K, Kristiansen K, Fagertun H, Vik H, Gudmundsen O.

Conjugated linoleic acid supplementation on Weight loss and Body fat composition

Conjugated linoleic acids (CLA) are a family of over 28 isomers of linoleic acid found abundantly in the meat and dairy products.
In this randomized, double-blind, placebo-controlled trial, subjects with a body mass index (BMI) of 24 to 35 kg/m(2) randomly received 1.7 g of cis-9,trans-11 and trans-10,cis-12 CLA (n = 30) or placebo (salad oil; n = 33) in 200 mL of sterilized milk twice daily for 12 wk, conducted by Kaohsiung Veterans General Hospital Pingtung Branch(1). In the sixty-three subjects completed the study (CLA, n = 30). After 12 wk, compared with the baseline, the BW, BMI, total fat mass, fat percentage, subcutaneous fat mass, and waist-to-hip ratio decreased in the CLA group (P < 0.05). The CLA group was stratified by BMI and gender. The BW, BMI, subcutaneous fat mass, and waist-to-hip ratio decreased in 27 subjects with a BMI ≥ 27, and these indices, except subcutaneous fat mass, were lower in female subjects. The levels of total cholesterol, triacylglycerol, low-density lipoprotein, and plasma fasting glucose increased, whereas those of high-density lipoprotein decreased after 3 mo of CLA treatment.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Effect of conjugated linoleic acid supplementation on weight loss and body fat composition in a Chinese population" by Chen SC, Lin YH, Huang HP, Hsu WL, Houng JY, Huang CK.

Body composition with Conjugated linoleic acid.

Conjugated linoleic acids (CLA) are a family of over 28 isomers of linoleic acid found abundantly in the meat and dairy products.
Conjugated linoleic acid has been shown to reduce body fat accumulation in several animal models and CLA reduces body fat accumulation whether animals are fed a high-fat or low-fat diet, as the mechanism involved in reducing body fat by increased energy expenditure, which is observed within one week of CLA feeding and is sustained for at least six weeks. The increased energy expenditure is sufficient to account for the decreased fat accumulation(1)

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Changes in body composition with conjugated linoleic acid" by DeLany JP, West DB.

Conjugated linoleic acid and Obesity control

Conjugated linoleic acids (CLA) are a family of over 28 isomers of linoleic acid found abundantly in the meat and dairy products. As obesity is associated with high blood cholesterol and high risk for developing diabetes and cardiovascular disease. Therefore, management of body weight and obesity are increasingly considered as an important approach to maintaining healthy cholesterol profiles and reducing cardiovascular risk. In the review of a few studies in mice fed CLA mixtures with different ratios of c9t11 and t10c12 isomers have indicated that the t10c12 isomer CLA may be the active form of CLA affecting weight gain and fat deposition. Inductions of leptin reduction and insulin resistance are the adverse effects of CLA observed in only mice, but the effect on Pid is inconsistent. A number of human studies suggest that CLA supplementation has no effect on body weight and insulin sensitivity. Although it is suggested that the t10c12 CLA is the antiadipogenic isomer of CLA in humans, the effects of CLA on fat deposition are marginal and more equivocal as compared to results observed in animal studies(1)

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Conjugated linoleic acid and obesity control: efficacy and mechanisms" by Wang YW, Jones PJ.

Conjugated linoleic acid (CLA) and Body fat accumulation

Conjugated linoleic acids (CLA) are a family of at least 28 isomers of linoleic acid found abundantly in the meat and dairy products.
In 2 experiments using relatively old mice (older than 6 mo): experiment 1, supplementation of CLA during dietary restriction and experiment 2, supplementation during ad libitum feeding followed by restriction. In both experiments, CLA exerted modulation of body fat independent of reduced food intake. Based on these results, researchers concluded that CLA may be more effective at protecting against fat mass regain following weight loss than as a weight loss treatment(1)

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Conjugated linoleic acid (CLA) prevents body fat accumulation and weight gain in an animal model" by Park Y, Albright KJ, Storkson JM, Liu W, Pariza MW.

Conjugated linoleic acid and Body fat mass

Conjugated linoleic acids (CLA) are a family of at least 28 isomers of linoleic acid found abundantly in the meat and dairy products. In the randomized, double-blind study including 60 overweight or obese volunteers (body mass index 25-35 kg/m(2)) divided into five groups receiving placebo (9 g olive oil), 1.7, 3.4, 5.1 or 6.8 g conjugated linoleic acid per day for 12 wk, 47 completed the study, conducted by Scandinavian Clinical Research AS(1), indicated that conjugated linoleic acid may reduce BFM in humans and that no additional effect on BFM is achieved with doses > 3.4 g CLA/d.(1)

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Conjugated linoleic acid reduces body fat mass in overweight and obese humans" by
Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O.

Conjugated linoleic acid and Weight Loss

Conjugated linoleic acids (CLA) are a family of at least 28 isomers of linoleic acid found abundantly in the meat and dairy products.
Postmenopausal women have a higher rate of obesity than premenopausal women, as the leevls of estrogen are reduced, leading postmenstrual women suceptible to weight gain and obesity in females. The OVX mice were fed with a high-fat diet containing CLA for 3 months. Mice had significantly reduced body weight gain compared with OVX mice fed with a high-fat diet without CLA. in the study conducted by Beckman Research Institute of the City of Hope(1)

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Conjugated linoleic acid reduces body weight gain in ovariectomized female C57BL/6J mice" by Kanaya N, Chen S.

Risk-benefit analysis of a hCG-500 kcal reducing diet

Human chorionic gonadotropin or human chorionic gonadotrophin (hCG) is a hormone produced during pregnancy, made by the developing embryo after conception.
In the review of the British physician A.T.W. Simeons' combined a reduction diet (500 kcal per day) with daily injections of the pregnancy hormone human chorionic gonadotropin (hCG) (125 IU i.m.), showed that showed a significant weight reduction during dieting, but no differences between treatment groups in respect of body weight, body proportions and feeling of hunger. One of them is the only German study conducted by Rabe et al. in 1981 in which 82 randomised premenopausal volunteers had been dieting either with hCG or without hCG injections. In recent publications describing mostly well-documented double-blind studies authors largely reject hCG administration in dieting. Supporters of the hCG diet must prove the efficacy of this method in controlled studies according to the German Drug Law. Until then the opinion of the German steroid toxicology panel is still valid, that hCG is ineffective in dieting and should not be used (Bolt 1982 a, 1982 b)(1)

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "[Risk-benefit analysis of a hCG-500 kcal reducing diet (cura romana) in females].
[Article in German]" byRabe T, Richter S, Kiesel L, Runnebaum B.

The prevention and treatment of overweight and obesity

In the presents the highlights of an advisory report on the prevention and treatment of overweight and obesity, produced by the Health Council of The Netherlands,
researchers indicated that healthy diet (including plenty of fruit, vegetables and cereal products) and at least one hour a day of moderate physical activity are recommended for the maintenance of energy balance and for the prevention of weight gain. While genetic factors play a part in the development of overweight and obesity, environmental factors appear to be of overriding importance. The so-called 'obesogenic environment' prompts individuals to eat more and to take less exercise. There are still no effective intervention strategies for the prevention of weight gain. However, the explosive increase in the prevalence of obesity and of its associated serious medical problems demands a common-sense approach involving preventive interventions, which are based on modern views of health promotion. These interventions require a broad coalition of actors, in which local and national authorities, industry, the healthcare system and the population at risk must each shoulder their own share of responsibility. The primary aim of obesity treatment should be a long-lasting weight loss of about 10%. Even this relatively small weight loss can produce significant health gains. Treatment methods must involve an integrated (lifestyle) approach, dependent on the amount of overweight involved and on the presence of comorbidity. Obesity should be treated chronically and prevention of weight regain must be part of any obesity treatment programme.(1)

101 Practical Weight Loss Tips
How you can lose way the natural wayUn-cover an amazingly simple way of losing weight

(1) "The prevention and treatment of overweight and obesity. Summary of the advisory report by the Health Council of The Netherlands" by Kemper HC, Stasse-Wolthuis M, Bosman W.

Effect of weight reduction on cardiovascular risk factors

Overweight or obese is aleady proven to be associated with an increased risk for the development of non-insulin-dependent diabetes mellitus, hypertension, and cardiovascular disease, etc. In the study of the effect of a low calorie diet in combination with oral supplementation by vitamins, minerals, probiotics and human chorionic gonadotropin (hCG, 125-180 IUs) on the body composition, lipid profile and CD34-positive cells in circulation. During this dieting program, the following parameters were assessed weekly for all participants: fat free mass, body fat, BMI, extracellular/intracellular water, total body water and basal metabolic rate. For part of participants blood chemistry parameters and circulating CD34-positive cells were determined before and after dieting. The data indicated that the treatments not only reduced body fat mass and total mass but also improved the lipid profile. The changes in body composition correlated with the level of lipoproteins responsible for the increased cardiovascular risk factors. These changes in body composition and lipid profile parameters coincided with the improvement of circulatory progenitor cell numbers(1)

101 Practical Weight Loss Tips
How you can lose way the natural wayUn-cover an amazingly simple way of losing weight


(1) "Effect of weight reduction on cardiovascular risk factors and CD34-positive cells in circulation" by Mikirova NA, Casciari JJ, Hunninghake RE, Beezley MM.

Low-dose hCG administration enhance preganacy with hypothalamic amenorrhea due to weight loss

Human chorionic gonadotropin or human chorionic gonadotrophin (hCG) is a hormone produced during pregnancy, made by the developing embryo after conception.
In the evaluation of a 24-year-old woman with weight loss-related amenorrhea underwent ovulation induction and intracytoplasmic sperm injection (ICSI). Administration of exogenous gonadotropins was ineffective in ovulation induction. Supplementation with low-dose hCG in order to increase luteinizing hormone (LH) activity in the late follicular phase produced late folliculogenesis and steroidogenesis, and ovulation was then successfully induced(1)

101 Practical Weight Loss Tips
How you can lose way the natural wayUn-cover an amazingly simple way of losing weight

(1) "Successful pregnancy following low-dose hCG administration in addition to hMG in a patient with hypothalamic amenorrhea due to weight loss" by Tsutsumi R, Fujimoto A, Osuga Y, Harada M, Takemura Y, Koizumi M, Yano T, Taketani Y.

human chorionic gonadotropin in weight reduction:

Human chorionic gonadotropin or human chorionic gonadotrophin (hCG) is a hormone produced during pregnancy, made by the developing embryo after conception.
In Laboratory studies of twenty of 25 in the HCG and 21 of 26 patients in the placebo groups completed 28 injections, researchers found that here was no statistically significant difference in the means of the two groups in number of injections received, weight loss, percent of weight loss, hip and waist circumference, weight loss per injections, or in hunger ratings. HCG does not appear to enhance the effectiveness of a rigidly imposed regimen for weight reduction(1)

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Ineffectiveness of human chorionic gonadotropin in weight reduction: a double-blind study" by Stein MR, Julis RE, Peck CC, Hinshaw W, Sawicki JE, Deller JJ Jr.

Human chorionic gonadotropin (HCG) and treatment of obesity

Human chorionic gonadotropin or human chorionic gonadotrophin (hCG) is a hormone produced during pregnancy, made by the developing embryo after conception.
In a double-blind randomized trial using injections of HCG or placebo, researchers found that weight loss was identical between the two groups, and there was no evidence for differential effects on hunger, mood or localized body measurements. Placebo injections, therefore, appear to be as effective as HCG in the treatment of obesity(1)

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Human chorionic gonadotropin (HCG) in the treatment of obesity: a critical assessment of the Simeons method" by Greenway FL, Bray GA.

Weight loss and serum 25-hydroxyvitamin D

Even though large observational studies and surveys have shown that obesity is independently associated with lower serum 25-hydroxyvitamin D (25[OH]D) concentration but data collected, conducted by University of California (1) from 383 overweight or obese women who participated in a 2-year clinical trial of a weight loss program, in which 51% (N=195) lost at least 5% of baseline weight by 24 months: 18% (N=67) lost 5-10%, and 33% (N=128) lost >10%. Women who did not lose weight at 24 months had an increase in serum 25(OH)D of 1.9 (9.7) ng/mL (mean [s.d.]); 25(OH)D increased by 2.7 (9.1) ng/mL for those who lost 5-10% of baseline weight; and 25(OH)D increased by 5.0 (9.2) ng/mL for those who lost >10% of baseline weight (P = 0.014). At baseline, 51% (N=197) of participants met or exceeded the recommended serum concentration of 20 ng/mL. And suggest that weight loss, presumably associated with a reduction in body fat, is associated with increased serum 25(OH)D concentration in overweight or obese women.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Weight loss is associated with increased serum 25-hydroxyvitamin D in overweight or obese women" by Rock CL, Emond JA, Flatt SW, Heath DD, Karanja N, Pakiz B, Sherwood NE, Thomson CA., posted in PubMed

Effectiveness and cost-effectiveness of bariatric (weight loss) surgery for obesity

In the effective review of 26 of a total of 5386 references in three randomised controlled trials (RCTs) and three cohort studies compared surgery with non-surgical interventions and 20 RCTs compared different surgical procedures, conducted by University of Southampton(1), showed that bariatric surgery appears to be a clinically effective and cost-effective intervention for moderately to severely obese people compared with non-surgical interventions, but uncertainties remain and further research is required to provide detailed data on patient QoL; impact of surgeon experience on outcome; late complications leading to reoperation; duration of comorbidity remission; resource use. Good-quality RCTs will provide evidence on bariatric surgery for young people and for adults with class I or class II obesity. The team aslo suggested that new research must report on the resolution and/or development of comorbidities such as Type 2 diabetes and hypertension so that the potential benefits of early intervention can be assessed.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "The clinical effectiveness and cost-effectiveness of bariatric (weight loss) surgery for obesity: a systematic review and economic evaluation" by Picot J, Jones J, Colquitt JL, Gospodarevskaya E, Loveman E, Baxter L, Clegg AJ., post in PubMed

Electronic Tools to Assist with Identification and Counseling for Overweight Patients:

In the identification of recognition, when patients are overweight and infrequently counsel them about weight loss. Evaluate a set of electronic health record (EHR)-embedded tools to assist with identification and counseling of overweight patients has become extreme important, as patients of physicians receiving the intervention were more likely than those of usual care physicians to receive a diagnosis of overweight (22% vs. 7%; p = 0.02) and weight-specific counseling (27% vs. 15%; p = 0.02). Most patients receiving counseling in the intervention group reported increased motivation to lose weight (90%) and taking steps toward their goal (93%). Most intervention physicians agreed that the tool alerted them to patients they did not realize were overweight (91%) and improved the effectiveness of their counseling (82%); more than half (55%) reported counseling overweight patients more frequently (55%). However, most physicians used the tool infrequently because of time barriers(1)

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Electronic Tools to Assist with Identification and Counseling for Overweight Patients: a Randomized Controlled Trial" By Tang JW, Kushner RF, Cameron KA, Hicks B, Cooper AJ, Baker DW., posted in PubMed

Low-carbohydrate versus conventional weight loss diets in severely obese adults

In the study of 132 obese adults with a body mass index of 35 kg/m2 or greater; 83% had diabetes or the metabolic syndrome, received counseling to either restrict carbohydrate intake to <30 g per day (low-carbohydrate diet) or to restrict caloric intake by 500 calories per day with <30% of calories from fat (conventional diet), conducted by University of Pennsylvania Medical Center, and Drexel University College of Medicine(1), with changes in weight, lipid levels, glycemic control, and insulin sensitivity were measured. The result indicated that Participants on a low-carbohydrate diet had more favorable overall outcomes at 1 year than did those on a conventional diet. Weight loss was similar between groups, but effects on atherogenic dyslipidemia and glycemic control were still more favorable with a low-carbohydrate diet after adjustment for differences in weight loss.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial" by Stern L, Iqbal N, Seshadri P, Chicano KL, Daily DA, McGrory J, Williams M, Gracely EJ, Samaha FF., posted in PubMed

Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet.

In this 2-year trial, we randomly assigned 322 moderately obese subjects (mean age, 52 years; mean body-mass index [the weight in kilograms divided by the square of the height in meters], 31; male sex, 86%) to one of three diets: low-fat, restricted-calorie; Mediterranean, restricted-calorie; or low-carbohydrate, non-restricted-calorie, conducted by Ben-Gurion University of the Negev(1), scientists found that Mediterranean and low-carbohydrate diets may be effective alternatives to low-fat diets. The more favorable effects on lipids (with the low-carbohydrate diet) and on glycemic control (with the Mediterranean diet) suggest that personal preferences and metabolic considerations might inform individualized tailoring of dietary interventions.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight


(1) "Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet" by Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I, Golan R, Fraser D, Bolotin A, Vardi H, Tangi-Rozental O, Zuk-Ramot R, Sarusi B, Brickner D, Schwartz Z, Sheiner E, Marko R, Katorza E, Thiery J, Fiedler GM, Blüher M, Stumvoll M, Stampfer MJ; Dietary Intervention Randomized Controlled Trial (DIRECT) Group., posted in PubMed

The ketogenic diet as a treatment option in adults with chronic refractory epilepsy

The ketogenic diet (KD) is defined as a high-fat, low-protein, low-carbohydrate diet, used commonly as a treatment for patients with difficult-to-control epilepsy. In a study conducted by Department of Neurology, Epilepsy Centre Kempenhaeghe(1) of 15 adults treated with the classical diet or MCT diet, during a follow-up period of 1 year, assessment of seizure frequency, seizure severity, tolerability, cognitive performance, mood and quality of life (QOL) were reported. By Analyzing the study months separately, researchers found that a seizure reduction of ≥50% in 26.6% of the patients during at least 1month of treatment. Common side-effects were gastrointestinal disorders, loss of weight and fatigue. There was a considerable, non-significant improvement found in mood and QOL scores. Improvements were independent of reduction in seizure frequency, indicating that the effects of the KD reach further than seizure control.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight


(1) "The ketogenic diet as a treatment option in adults with chronic refractory epilepsy: Efficacy and tolerability in clinical practice" by Lambrechts DA, Wielders LH, Aldenkamp AP, Kessels FG, de Kinderen RJ, Majoie MJ., posted in PubMed

Green tea on weight loss and weight maintenance

There have been different outcomes of the effect of green tea on weight loss (WL) and weight maintenance (WM) have been reported in studies with subjects differing in ethnicity and habitual caffeine intake. In the review conducted by Nutrition and Toxicology Research Institute Maastricht (NUTRIM) Maastricht University(1), out of the 49 studies initially identified, a total of 11 articles fitted the inclusion criteria and provided useful information for the meta-analysis. Effect sizes (mean weight change in treatment versus control group) were computed and aggregated based on a random-effects model. researchers concluded that Catechins significantly decreased body weight and significantly maintained body weight after a period of WL (microcirc=-1.31 kg; P<0.001). Inhibition of this effect by high habitual caffeine intake (>300 mg per day) failed to reach significance (microcirc=-0.27 kg for high and microcirc=-1.60 kg for low habitual caffeine intake; P=0.09). Also, the seemingly smaller effect of catechins in Caucasian (microcirc=-0.82 kg) subjects compared with Asians (microcirc=-1.51 kg; P=0.37) did not reach significance. Interaction of ethnicity and caffeine intake was a significant moderator (P=0.04).

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight


(1) "The effects of green tea on weight loss and weight maintenance: a meta-analysis" by Hursel R, Viechtbauer W, Westerterp-Plantenga MS., posted in PubMed

Green tea on weight maintenance

In the investigation of whether green tea may improve weight maintenance by preventing or limiting weight regain after weight loss of 5 to 10 % in overweight and moderately obese subjects. A randomised, parallel, placebo-controlled design, conducted by Maastricht University (1). A total of 104 overweight and moderately obese male and female subjects (age 18-60 years; BMI 25-35 kg/m(2)) participated. The study consisted of a very-low-energy diet intervention (VLED; 2.1 MJ/d) of 4 weeks followed by a weight-maintenance period of 13 weeks in which the subjects received green tea or placebo. The result showed that in the green tea treatment, habitual high caffeine consumption was associated with a higher weight regain compared with habitual low caffeine consumption (39 (sd 17) and 16 (sd 11) %, respectively; P<0.05).

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Effects of green tea on weight maintenance after body-weight loss" by Kovacs EM, Lejeune MP, Nijs I, Westerterp-Plantenga MS., posted in PubMed

Green tea extract thermogenesis-induced Weight loss

Intake of tea catechins is associated with a lower risk of cardiovascular disease. The antioxidative activity of tea-derived catechins has been extensively studied, as well as it is associated with increased weight loss due to diet-induced thermogenesis, by inhibiting catechol-O-methyltransferase (the enzyme that degrades norepinephrine) as the result of stimulating thermogenesis by epigallocatechin gallate to augment and prolong sympathetic stimulation of thermogenesis, according to the st5udy conducted by South China Institute of Botany, Chinese Academy of Sciences(1)

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight


(1) Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase" by Shixian Q, VanCrey B, Shi J, Kakuda Y, Jiang Y., posted in PubMed

Dietary carbohydrate and fat and diabetes

In the review of the emphasis in recent years has been on the reduction of total fat and saturated fat and replacement with complex carbohydrate. Scientist from the Stanford University School of Medicine(1) indicated that there is little evidence to support the notion that low-fat high-carbohydrate diets per se lead to any reduction in the risk for CAD in individuals with diabetes from the available data, but the only data indicating that low-fat high-carbohydrate diets lead to beneficial effects on carbohydrate and lipoprotein metabolism are confounded either by the lack of suitable experimental control. The group said that diets also differed in the type of dietary fat and amount of dietary cholesterol, or were enormously enriched in dietary fiber. When these factors are taken into consideration, there appears to be little evidence in support of the view that substituting carbohydrate for fat in the diets of individuals with diabetes results in any measurable beneficial effect.
The group continued that indeed, it could be argued that the most characteristic defects in carbohydrate and lipoprotein metabolism are exacerbated in response to low-fat high-carbohydrate diets. Alternatively, the data presented herein strongly suggest that diets containing conventional quantities of fat, in which saturated fat is replaced by unsaturated fat and dietary cholesterol reduced, would result in the desired reductions to total and low-density lipoprotein cholesterol concentrations without the adverse effects of increased postprandial glucose and insulin concentrations, increased fasting and postprandial total and very-low-density lipoprotein triglyceride concentrations, and decreased fasting high-density lipoprotein cholesterol concentrations.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight


(1) "Effects of dietary carbohydrate and fat intake on glucose and lipoprotein metabolism in individuals with diabetes mellitus" by Hollenbeck CB, Coulston AM., posted in PubMed

Trans monounsaturated fatty acids or saturated fatty acids in obese patients with NIDDM

In general assumption that high intake of trans fatty acids and saturated fatty acids (SFAs) is known to increase the risk of coronary heart disease, but whether the effects of diets enriched in various fatty acids on postprandial insulinemia and fasting serum levels of lipids and lipoproteins in obese patients with NIDDM is to be determined.
In the study of 16 obese NIDDM patients in a free-living outpatient regimen, after a run-in period, the patients received three different isocaloric diets for 6 weeks using a randomized crossover design. The patients were instructed to keep the energy intake from carbohydrate and protein constant at 50 and 20 E% (percent of energy intake), respectively, on all three diets. The fat composition of the diets differed: saturated fat (SAT) diet (20 E% SFAs, 5 E% polyunsaturated fatty acids [PUFAs], and 5 E% monounsaturated fatty acids [MUFAs]) versus cis monounsaturated fatty acid (CMUFA) diet (20 E% cis-MUFAs, 5 E% PUFAs, and 5 E% SFAs) versus trans monounsaturated fatty acid (TMUFA) diet (20 E% trans-MUFAs, 5 E% PUFAs, and 5 E% SFAs, the group filed the result that in the presence of unchanged glycemia, both dietary trans fatty acids and SFAs induce an increase in postprandial insulinemia in obese patients with NIDDM.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight


(1) "Intake of a diet high in trans monounsaturated fatty acids or saturated fatty acids. Effects on postprandial insulinemia and glycemia in obese patients with NIDDM" by Christiansen E, Schnider S, Palmvig B, Tauber-Lassen E, Pedersen O., posted in PubMed

Monounsaturated fatty acids and obese NIDDM patients.

In the dettermination of whether the response to weight loss can be improved by altering the macronutrient composition of hypocaloric diets, 17 obese NIDDM patients were studied at I) baseline, 2) after dieting for 6 weeks on a formula diet enriched in either monounsaturated fatty acids (MUFAs, n = 9) or carbohydrates (CHOs, n = 8) at a 50% caloric deficit, and 3) after 4 weeks of postdiet refeeding on the respective formulas with caloric intake titrated to achieve weight maintenance, conducted by University of Rochester(1), the researchers said" macronutrient composition is an important determinant of the glycemic response to weight-loss therapy in obese NIDDM patients. Based on the C-peptide response during the OGTT, increased CHO-induced insulin secretion is one possible mechanism by which this occurs"

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight


(1) "Potentiation of effects of weight loss by monounsaturated fatty acids in obese NIDDM patients" by Low CC, Grossman EB, Gumbiner B., posted by PubMed

Monounsaturated fatty acid-enriched hypocaloric diet and Diabetes

Whether the lipoprotein response to weight loss in obese patients with type 2 diabetes can be improved by modifying the macronutrient composition of the commonly prescribed low-fat, high-carbohydrate (CHO) hypocaloric diet. In the investigation of nine obese patients with type 2 diabetes treated with a monounsaturated fatty acid (MUFA)-enriched weight-reducing formula diet and compared with eight obese patients with type 2 diabetes treated with a low-fat, high-CHO weight-reducing formula diet. Weight loss ensued for 6 weeks, followed by 4 weeks of refeeding using isocaloric formulas enriched with MUFA or CHO, respectively, conducted by Indiana University Center for Weight Management, National Institute for Fitness and Sport(1), the result showed that there were no differences between the groups in plasma lipids, lipoproteins, or LDL susceptibility to oxidation. Weight loss was similar between the groups. Dieting resulted in decreases in total plasma cholesterol, LDL, HDL, triglycerides, and apolipoproteins A and B (P < 0.05), but the MUFA group manifested a greater decrease in total cholesterol, triglycerides, and apolipoprotein B and a smaller decrease in HDL and apolipoprotein A than the CHO group (P < 0.05). Improvements in these parameters were sustained during refeeding. After dieting, lag time was prolonged in the MUFA group (208 +/- 10 min) compared with the CHO group (146 +/- 11 min; P < 0.05). Lag time was prolonged further during refeeding in the MUFA group (221 +/- 13 min, P = 0.10), while the CHO group remained unchanged (152 +/- 9 min, P < 0.05). Lag time correlated strongly with the oleic acid content of LDL after dieting and refeeding (r = 0.74 and r = 0.93, respectively; both P < 0.001).

(1) "Effects of a monounsaturated fatty acid-enriched hypocaloric diet on cardiovascular risk factors in obese patients with type 2 diabetes" by Gumbiner B, Low CC, Reaven PD., posted in PubMed

Diet for improving Glucose and Lipid profiles in Diabestes

In the searching an optimal diet for improving glucose and lipid profiles in obese patients with type 2 diabetes, 35 free-living obese patients with type 2 diabetes were assigned to one of three 1,600 kcal/day diets for 12 weeks. The diets were high carbohydrate (10% fat, 4% saturated), high monounsaturated fat (MUFA) (32% fat, 7% saturated), or high saturated fat (SFA) (32% fat, 17% saturated), conducted by University of Adelaide (1) Scientists found that energy restriction, independent of diet composition, improves glycemic control; however, reducing SFA intake by replacing SFA with carbohydrate or MUFA reduces LDL maximally during weight loss and to a greater degree than has been shown in weight-stable studies.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight


(1) "Effect of energy restriction, weight loss, and diet composition on plasma lipids and glucose in patients with type 2 diabetes" by Heilbronn LK, Noakes M, Clifton PM., posted in PubMed

The Efficacy of High protein vs High carbohydrate diets in Diabetes

Extremely low carbohydrate/high protein diets are popular methods and well known of weight loss, but compliance to the diet program is poor . In the evaluation of that six patients with type 2 diabetes (five women and one man) were randomly assigned to the high-protein diet (40% carbohydrate, 30% protein, 30% fat) and six patients (four women and two men) to the high-carbohydrate diet (55% carbohydrate, 15% protein, 30% fat). All patients returned to the General Clinical Research Center weekly for monitoring of food records; dietary compliance; and measurements of body weight, blood pressure, and blood glucose. After 8 weeks on these diets, conducted by Drexel University (1). Scientists filed the result of that the high-carbohydrate and high-protein groups lost weight (-2.2+/-0.9 kg, -2.5+/-1.6 kg, respectively, P <.05) and the difference between the groups was not significant (P =.9). In the high-carbohydrate group, hemoglobin A1c decreased (from 8.2% to 6.9%, P <.03), fasting plasma glucose decreased (from 8.8 to 7.2 mmol/L, P <.02), and insulin sensitivity increased (from 12.8 to 17.2 micromol/kg/min, P <.03). No significant changes in these parameters occurred in the high-protein group, instead systolic and diastolic blood pressures decreased (-10.5+/-2.3 mm Hg, P =.003 and -18+/-9.0 mm Hg, P <.05, respectively). After 2 months on these hypocaloric diets, each diet had either no or minimal effects on lipid levels (total cholesterol, low-density lipoprotein, high-density lipoprotein), renal (blood urea nitrogen, serum creatinine), or hepatic function (aspartate aminotransferase, alanine aminotransferase, bilirubin).

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight


(1) "Effect of high protein vs high carbohydrate intake on insulin sensitivity, body weight, hemoglobin A1c, and blood pressure in patients with type 2 diabetes mellitus"
Sargrad KR, Homko C, Mozzoli M, Boden G, Posted in PubMed

Very-low-carbohydrate diet vs High-carbohydrate diet In Renal Function

Low-carbohydrate diets or low-carb diets are defined as a dietary programs that reduce the consumption of carbohydrate for weight control or for the treatment of obesity.
High-carbohydrate diet is the maximun intake of carbohydrate dietary programs. Some experts indicated that the program also promotes weight loss and reduce the risk of obesity(a)
There is always a concern that very-low-carbohydrate diets is the potential for increased risk of renal disease associated with a higher protein intake. In the assessment of renal function in 68 men and women with abdominal obesity (age 51.5+/-7.7 years, body mass index [calculated as kg/m(2)] 33.6+/-4.0) without preexisting renal dysfunction who were randomized to consume either an energy-restricted ( approximately 1,433 to 1,672 kcal/day), planned isocaloric very-low-carbohydrate (4% total energy as carbohydrate [14 g], 35% protein [124 g], 61% fat [99 g]), or high-carbohydrate diet (46% total energy as carbohydrate [162 g], 24% protein [85 g], 30% fat [49 g]) for 1 year. Body weight, serum creatinine, estimated glomerular filtration rate and urinary albumin excretion were assessed before and after 1 year , conducted by Commonwealth Scientific and Industrial Research Organisation(1), showed that long-term weight loss with a very-low-carbohydrate diet does not adversely affect renal function compared with a high-carbohydrate diet in obese individuals with normal renal function.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight


(a) http://www.blogger.com/post-create.g?blogID=3714065621840877985
(1) http://www.ncbi.nlm.nih.gov/pubmed/20338292

Green Tea, High Protein Diet and Weight Maintenance (WM) After Body Weight Loss

In the investigation of the effect of a green tea-caffeine mixture added to a high-protein (HP) diet on weight maintenance (WM) after body weight loss in moderately obese subjects, conducted by Maastricht University(1) of a randomized, placebo-controlled, double-blind parallel trial in 80 overweight and moderately obese subjects [age (mean +/- SD): 44 +/- 2 y; body mass index (BMI; in kg/m(2)): 29.6 +/- 2.0] matched for sex, age, BMI, height, body mass, and with a habitually low caffeine intake. A very-low-energy diet intervention during 4 wk was followed by 3 mo of WM; during the WM period, the subjects received a green tea-caffeine mixture (270 mg epigallocatechin gallate + 150 mg caffeine/d) or placebo, both in addition to an adequate protein (AP) diet (50-60 g protein/d) or an HP diet (100-120 g protein/d), concluded that The green tea-caffeine mixture, as well as the HP diet, improved WM independently through thermogenesis, fat oxidation, sparing FFM, and, for the HP diet, satiety; a possible synergistic effect failed to appear.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Green tea catechin plus caffeine supplementation to a high-protein diet has no additional effect on body weight maintenance after weight loss" by Hursel R, Westerterp-Plantenga MS., Posted in PubMed

Low-fat diets for obesity

In the review of studies of participants who fulfilled the following criteria: 1) they were randomised controlled clinical trials of low-fat diets versus other weight-reducing diets, 2) the primary purpose of the study was weight loss, 3) participants were followed for at least six months, 4) the study participants were adults (18 years or older) who were overweight or obese (BMI >25 kg/m2) at baseline. Studies including pregnant women or patients with serious medical conditions were excluded. Two people independently applied the inclusion criteria to the studies identified. Disagreement was resolved by discussion or by intervention of a third party, conducted by University of Teesside (1) focused primarily on participants who were overweight or clinically obese and were dieting for the purpose of weight reduction. Since we were particularly interested in the ability of participants to sustain weight loss over a longer period of time, we focused on studies of 'free living' men and women who were given dietary advice rather than provision of food or money to purchase food. The review suggests that fat-restricted diets are no better than calorie restricted diets in achieving long term weight loss in overweight or obese people. Overall, participants lost slightly more weight on the control diets but this was not significantly different from the weight loss achieved through dietary fat restriction and was so small as to be clinically insignificant.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "WITHDRAWN: Advice on low-fat diets for obesity" by Summerbell CD, Cameron C, Glasziou PP., posted in PubMed(1)

Atkins, Zone, Ornish, and LEARN diets

In comparison of 4 weight-loss diets, representing a spectrum of low to high carbohydrate intake for effects on weight loss and related metabolic variables conducted by Stanford University Medical School(1) in a twelve-month randomized trial, randomly assigned to follow the Atkins (n = 77), Zone (n = 79), LEARN (n = 79), or Ornish (n = 76) diets and received weekly instruction for 2 months, then an additional 10-month follow-up, showed that premenopausal overweight and obese women assigned to follow the Atkins diet, which had the lowest carbohydrate intake, lost more weight at 12 months than women assigned to follow the Zone diet, and had experienced comparable or more favorable metabolic effects than those assigned to the Zone, Ornish, or LEARN diets [corrected] While questions remain about long-term effects and mechanisms, a low-carbohydrate, high-protein, high-fat diet may be considered a feasible alternative recommendation for weight loss.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial" by Gardner CD, Kiazand A, Alhassan S, Kim S, Stafford RS, Balise RR, Kraemer HC, King AC., Posted in Pubmed

Energy-restricted, High-protein, Low-fat diet and High-carbohydrate diet.

In the investigation of a diet with a high ratio of protein to carbohydrate during weight loss on body composition, cardiovascular disease risk, nutritional status, and markers of bone turnover and renal function in overweight women, conducted by CSIRO Health Sciences and Nutrition(1) by randomly assigned to 1 of 2 isocaloric 5600-kJ dietary interventions for 12 wk according to a parallel design: a high-protein (HP) or a high-carbohydrate (HC) diet. One hundred women with a mean (+/-SD) body mass index (in kg/m(2)) of 32 +/- 6 and age of 49 +/- 9 y completed the study, showed that an energy-restricted, high-protein, low-fat diet provides nutritional and metabolic benefits that are equal to and sometimes greater than those observed with a high-carbohydrate diet.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "Effect of an energy-restricted, high-protein, low-fat diet relative to a conventional high-carbohydrate, low-fat diet on weight loss, body composition, nutritional status, and markers of cardiovascular health in obese women" by Noakes M, Keogh JB, Foster PR, Clifton PM., posted in Pubmed

High-protein, Low fat or High-carbohydrate diet

In a random study of groups designated as control diet (CON), control diet with exercise (CONEx), high-protein (HP), or high-protein with exercise (HPEx). Free-living women from the Guelph community conducted by University of Guelph, Guelph. Actual diets consumed by the subjects contained ratios of carbohydrate to protein of 3.0:1, 2.7:1, 1.5:1, and 0.96:1 for the CON, CONEx, HP, and HPEx groups, respectively. Cardiovascular fitness improved in both exercise groups. There were no changes in resting energy expenditure. No adverse events were reported. Significant changes in blood lipids included decreased total cholesterol in the HP and CONEx groups, decreased low-density lipoprotein cholesterol in the HP group only, and decreased blood triglycerides in the HPEx group only. High-density lipoprotein cholesterol, fasting blood glucose, and fasting insulin levels were unaltered by diet or exercise. A high-protein diet was superior to a low-fat, high-carbohydrate diet either alone or when combined with an aerobic/resistance-training program in promoting weight loss and nitrogen balance, while similarly improving body composition and risk factors for the Metabolic Syndrome in overweight and obese Canadian women.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "A randomized trial of a hypocaloric high-protein diet, with and without exercise, on weight loss, fitness, and markers of the Metabolic Syndrome in overweight and obese women" by Meckling KA, Sherfey R., posted in Pubmed

Weight loss and High protein diet with Resistance Exercise Training

In a study conducted by Commonwealth Scientific and Industrial Research Organisation, Food and Nutritional Sciences (1), with an aim to determine the effectiveness of two low-fat hypocaloric diets differing in the carbohydrate-to-protein ratio, with and without resistance exercise training (RT), on weight loss, body composition, and cardiovascular disease (CVD) risk outcomes in overweight/obese patients with type 2 diabetes. A total of 83 men and women with type 2 diabetes (aged 56.1 +/- 7.5 years, BMI 35.4 +/- 4.6 kg/m(2)) were randomly assigned to an isocaloric, energy-restricted diet (female subjects 6 MJ/day, male subjects 7 MJ/day) of either standard carbohydrate (CON; carbohydrate:protein:fat 53:19:26) or high protein (HP; 43:33:22), with or without supervised RT (3 days/week) for 16 weeks. The result with fifty-nine participants completed the study indicated that an energy-restricted HP diet combined with resistance exercise training (RT) achieved greater weight loss and more favorable changes in body composition. All treatments had similar improvements in glycemic control and CVD risk markers.

101 Practical Weight Loss Tips
How you can lose way the natural way
Un-cover an amazingly simple way of losing weight

(1) "A high-protein diet with resistance exercise training improves weight loss and body composition in overweight and obese patients with type 2 diabetes" by

Wycherley TP, Noakes M, Clifton PM, Cleanthous X, Keogh JB, Brinkworth GD. Posted in PubMed