In the study of 3-month lifestyle intervention on insulin sensitivity and its related cardiometabolic factors in obese patients, conducted by Department of Medical Sciences and Rehabilitation(1)
found that Lifestyle intervention induces changes in insulin sensitivity and metabolic factors that depend on the pre-intervention degree of insulin sensitivity. Weight loss leads to metabolic benefits in insulin-resistant, obese patients, whereas it may paradoxically worsen the metabolic conditions in the insulin-sensitive phenotype of obesity(1)
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(1) "Insulin sensitivity deteriorates after short-term lifestyle intervention in the insulin sensitive phenotype of obesity" by Gilardini L, Vallone L, Cottafava R, Redaelli G, Croci M, Conti A, Pasqualinotto L, Invitti C.
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