Effect of weight reduction on cardiovascular risk factors

Overweight or obese is aleady proven to be associated with an increased risk for the development of non-insulin-dependent diabetes mellitus, hypertension, and cardiovascular disease, etc. In the study of the effect of a low calorie diet in combination with oral supplementation by vitamins, minerals, probiotics and human chorionic gonadotropin (hCG, 125-180 IUs) on the body composition, lipid profile and CD34-positive cells in circulation. During this dieting program, the following parameters were assessed weekly for all participants: fat free mass, body fat, BMI, extracellular/intracellular water, total body water and basal metabolic rate. For part of participants blood chemistry parameters and circulating CD34-positive cells were determined before and after dieting. The data indicated that the treatments not only reduced body fat mass and total mass but also improved the lipid profile. The changes in body composition correlated with the level of lipoproteins responsible for the increased cardiovascular risk factors. These changes in body composition and lipid profile parameters coincided with the improvement of circulatory progenitor cell numbers(1)

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(1) "Effect of weight reduction on cardiovascular risk factors and CD34-positive cells in circulation" by Mikirova NA, Casciari JJ, Hunninghake RE, Beezley MM.