Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression

In a study to evaluated 12 wk of exercise (aerobic and resistance) or 12 wk of weight loss (approximately 7% reduction) on skeletal muscle mRNAs for toll-like receptor-4 (TLR-4), mechanogrowth factor (MGF), TNF-alpha, and IL-6 in 16 obese (body mass index 38+/-2 kg/m2) older (69+/-1 yr) physically frail individuals, indicated that exercise but not weight loss had a beneficial effect on markers of muscle inflammation and anabolism in frail obese elderly individuals(1).

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(1) "Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons" by Lambert CP, Wright NR, Finck BN, Villareal DT.